2017-09-24 Welcome guest,  Sign In  |  Sign Up
Chin. Opt. Lett.
 Home  List of Issues    Issue 09 , Vol. 15 , 2017    10.3788/COL201715.090007

Feasibility study of phase-sensitive imaging based on multiple reference optical coherence tomography
Roshan Dsouza1;2, Hrebesh Subhash3, Kai Neuhaus1, Paul M. McNamara1;2, Josh Hogan4, Carol Wilson4, and Martin J. Leahy1;5
1 Tissue Optics and Microcirculation Imaging Group, School of Physics, [National University of Ireland], Galway H91 CF50, Ireland
2 [Compact Imaging Ireland Ltd.], Galway H91 CF50, Ireland
3 [Colgate-Palmolive Global Technology Centre], Piscataway NJ 08855, USA
4 [Compact Imaging, Inc.], Mountain View 94 04 3, USA
5 [Royal College of Surgeons (RCSI)], Dublin, Ireland

Chin. Opt. Lett., 2017, 15(09): pp.090007

Keywords(OCIS Code): 110.4500  100.3175  120.5050  280.2490  

Multiple reference optical coherence tomography (MR-OCT) is a recently developed, low-cost and compact time-domain OCT solution for primary care and consumer level applications. A combination of a voice coil actuator and a partial mirror (PM) extends the scan range for imaging depths of approximately 1 mm in biological samples. Our previous research on MR-OCT is based only on intensity information obtained from the depth-resolved interference signal. In this Letter, we extract the phase information from the MR-OCT signal and, hence, provide an additional contrast modality. The phase sensitivity of the system is measured to be approximately 0.2 and 1.5 rad for the first and twelfth orders of reflection when using a mirror as the sample. This Letter describes first results of phase-sensitive data measured on a phantom obtained with MR-OCT. Data from a chick embryo chorioallantoic membrane (CAM) is used to demonstrate the feasibility of MR-OCT for in vivo phase-sensitive imaging.

Copyright: © 2003-2012 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 View PDF (816 KB)


Posted online:2017/8/23

Get Citation: Roshan Dsouza, Hrebesh Subhash, Kai Neuhaus, Paul M. McNamara, Josh Hogan, Carol Wilson, and Martin J. Leahy, "Feasibility study of phase-sensitive imaging based on multiple reference optical coherence tomography," Chin. Opt. Lett. 15(09), 090007(2017)

Note: We thank Barbara Coen from the Physiology Department at NUI Galway for providing the CAsM and James McGrath for providing the infrared heat lamp. This work was supported by the Galway University Foundation, the University of Limerick Foundation, the National Biophotonics Imaging Platform (NBIP) Ireland, funded under the Higher Education Authority PRTLI Cycle 4, co-funded by the Irish Government and the European Union Investing in your future, and Compact Imaging, Inc. All authors have a financial interest in Compact Imaging, Inc.


1. E. A. Swanson, “Optical coherence tomography: Beyond better clinical care: OCT’s economic impact ,” http://www.bioopticsworld.com/articles/print/volume-9/issue-6/optical-coherence-tomography-beyond-better-clinical-care-oct-s-economic-impact.html.

2. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).

3. M. Choma, M. Sarunic, C. Yang, and J. Izatt, Opt. Express 11, 2183 (2003).

4. R. Leitgeb, C. Hitzenberger, and A. Fercher, Opt. Express 11, 889 (2003).

5. W. Drexler, and J. G. Fujimoto, Optical Coherence Tomography: Technology and Applications (Springer Science & Business Media, 2008).

6. W. Jung, J. Kim, M. Jeon, E. J. Chaney, C. N. Stewart, and S. A. Boppart, IEEE Trans. Biomed. Eng. 58, 741 (2011).

7. R. L. Shelton, W. Jung, S. I. Sayegh, D. T. McCormick, J. Kim, and S. A. Boppart, J. Biophoton. 7, 525 (2014).

8. C. D. Lu, M. F. Kraus, B. Potsaid, J. J. Liu, W. Choi, V. Jayaraman, A. E. Cable, J. Hornegger, J. S. Duker, and J. G. Fujimoto, Biomed. Opt. Express 5, 293 (2013).

9. D. Demian, V.-F. Duma, C. Sinescu, M. L. Negrutiu, R. Cernat, F. I. Topala, G. Hutiu, A. Bradu, and A. G. Podoleanu, Proc. Inst. Mech. Eng. [H] 228, 743 (2014).

10. V. D. Nguyen, B. I. Akca, K. W?rhoff, R. M. de Ridder, M. Pollnau, T. G. van Leeuwen, and J. Kalkman, Opt. Lett. 36, 1293 (2011).

11. V. D. Nguyen, N. Weiss, W. Beeker, M. Hoekman, A. Leinse, R. G. Heideman, T. G. van Leeuwen, and J. Kalkman, Opt. Lett. 37, 4820 (2012).

12. S. Schneider, M. Lauermann, P.-I. Dietrich, C. Weimann, W. Freude, and C. Koos, Opt. Express 24, 1573 (2016).

13. Z. Wang, H.-C. Lee, D. Vermeulen, L. Chen, T. Nielsen, S. Y. Park, A. Ghaemi, E. Swanson, C. Doerr, and J. Fujimoto, Biomed. Opt. Express 6, 2562 (2015).

14. P. Pande, R. L. Shelton, G. L. Monroy, R. M. Nolan, and S. A. Boppart, Biomed. Opt. Express 8, 338 (2016).

15. K. Osawa, H. Minemura, Y. Anzai, D. Tomita, T. Shimanaka, T. Suzuki, H. Iida, N. Matsuura, C. Katagiri, T. Yamashita, Y. Hara, and K. Watanabe, Appl. Opt. 55, 5052 (2016).

16. Z. Chen, T. E. Milner, D. Dave, and J. S. Nelson, Opt. Lett. 22, 64 (1997).

17. Z. Chen, T. E. Milner, S. Srinivas, X. Wang, A. Malekafzali, M. J. van Gemert, and J. S. Nelson, Opt. Lett. 22, 1119 (1997).

18. Y. Zhao, Z. Chen, C. Saxer, S. Xiang, J. F. de Boer, and J. S. Nelson, Opt. Lett. 25, 114 (2000).

19. Y. Zhao, Z. Chen, C. Saxer, Q. Shen, S. Xiang, J. F. de Boer, and J. S. Nelson, Opt. Lett. 25, 1358 (2000).

20. Y. Zhao, K. M. Brecke, H. Ren, Z. Ding, J. S. Nelson, and Z. Chen, IEEE J. Sel. Top. Quantum Electron. 7, 931 (2001).

21. J. N. Hogan, and C. J. Wilson, “Multiple reference non-invasive analysis system,” U.S. Patent US7526329 B2 (April28, 2009).

22. J. N. Hogan, “Frequency resolved imaging system,” U.S. Patent US7751862 B2 (July6, 2010).

23. M. J. Leahy, J. O’Doherty, P. McNamara, J. Henricson, G. E. Nilsson, C. Anderson, and F. Sjoberg, in Proc. SPIE 6535, 1 (2007).

24. R. Dsouza, H. Subhash, K. Neuhaus, J. Hogan, C. Wilson, and M. Leahy, Biomed. Opt. Express 5, 2870 (2014).

25. R. Dsouza, H. M. Subhash, K. Neuhaus, J. Hogan, C. Wilson, and M. Leahy, Appl. Opt. 54, 5634 (2015).

26. R. Dsouza, H. Subhash, K. Neuhaus, R. Kantamneni, P. M. McNamara, J. Hogan, C. Wilson, and M. Leahy, Lasers Surg. Med. 48, 77 (2016).

27. P. M. McNamara, R. Dsouza, C. O’Riordan, S. Collins, P. O’Brien, C. Wilson, J. Hogan, and M. J. Leahy, J. Biomed. Opt. 21, 126020 (2016).

28. R. I. Dsouza, “Towards low cost multiple reference optical coherence tomography for in vivo and NDT applications ,” Ph.D. Thesis (National University of Ireland Galway, 2016).

29. I. Grulkowski, I. Gorczynska, M. Szkulmowski, D. Szlag, A. Szkulmowska, R. A. Leitgeb, A. Kowalczyk, and M. Wojtkowski, Opt. Express 17, 23736 (2009).

30. Z. Ma, A. Liu, X. Yin, A. Troyer, K. Thornburg, R. K. Wang, and S. Rugonyi, Biomed. Opt. Express 1, 798 (2010).

31. H. Ding, J. Q. Lu, K. M. Jacobs, and X.-H. Hu, J. Opt. Soc. Am. A 22, 1151 (2005).

32. Z. Ding, Y. Zhao, H. Ren, J. S. Nelson, and Z. Chen, Opt. Express 10, 236 (2002).

Save this article's abstract as
Copyright©2014 Chinese Optics Letters 沪ICP备05015387