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Chin. Opt. Lett.
 Home  List of Issues    Issue 09 , Vol. 15 , 2017    10.3788/COL201715.090008

Combination of OCT and Raman spectroscopy for improved characterization of atherosclerotic plaque depositions
Kokila Egodage1;2, Christian Matth?us1;2, Sebastian Dochow1;2, Iwan W. Schie1;2, Carmen H?rdtner3, Ingo Hilgendorf3, and Jürgen Popp1;2
1 [Leibniz Institute of Photonic Technology], Albert Einstein Stra?e 9, Jena 07745, Germany
2 [Institute of Physical Chemistry and Abbe Center of Photonics], Friedrich-Schiller-University, Jena 07743, Germany
3 [University Heart Center Freiburg, Department of Cardiology and Angiology I], Faculty of Medicine, University of Freiburg, Germany

Chin. Opt. Lett., 2017, 15(09): pp.090008

Keywords(OCIS Code): 140.3550  170.4500  

The biochemical composition of atherosclerotic plaques is closely related to plaque stability and, therefore, to the associated risk of plaque evolution and rupture. Combinations of current imaging modalities, such as optical coherence tomography (OCT) with spectroscopic methods, therefore offer the possibility of concurrently obtaining morphological as well as chemical information. Raman spectroscopy is one of the most promising techniques that can be combined with intravascular imaging modalities. A microscopy setup merging both techniques has been applied to characterize plaque depositions of a human aorta affected by the disease. Calcified depositions were clearly identified and subsequently confirmed by histopathology.

Copyright: © 2003-2012 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Posted online:2017/8/30

Get Citation: Kokila Egodage, Christian Matth?us, Sebastian Dochow, Iwan W. Schie, Carmen H?rdtner, Ingo Hilgendorf, and Jürgen Popp, "Combination of OCT and Raman spectroscopy for improved characterization of atherosclerotic plaque depositions," Chin. Opt. Lett. 15(09), 090008(2017)

Note: This work was supported by the Carl Zeiss Foundation.


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